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Its primary psychoactive constituent is a diterpenoid known as salvinorin A a potent κ-opioid receptor agonist. Salvinorin A is unique in that it is the only naturally occurring substance known to induce a visionary state this way. Salvia divinorum can be chewed, smoked,or taken as a tincture to produce experiences ranging from uncontrollable laughter to much more intense and profoundly altered states. The duration is much shorter than for some other more well known psychedelics; the effects of smoked salvia typically last for only a few minutes. The most commonly reported after-effects include an increased feeling of insight and improved mood, and a sense of calmness and increased sense of connection with nature—though much less often it may also cause dysphoria (unpleasant or uncomfortable mood). Salvia divinorum is not generally understood to be toxic or addictive.
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